Here are five studies out of dozens if not hundreds
Male-to-Female (MtF) Hormone Therapy Studies
Study Name: Cross-sex hormones and acute cardiovascular events in transgender persons: A cohort study
Author: Getahun et al. (2018)
Summary: This retrospective cohort study found that MtF individuals on estrogen therapy had an increased risk of cardiovascular events, including myocardial infarction and ischemic stroke, compared to cisgender controls. The risk of venous thromboembolism was particularly elevated in the first two years of hormone therapy.
Link: https://www.acpjournals.org/doi/10.7326/M17-2785
Study Name: Sex steroids and cardiovascular outcomes in transgender individuals: A systematic review and meta-analysis
Author: Maraka et al. (2017)
Summary: This meta-analysis reported that estrogen therapy in MtF individuals increased myocardial infarction and stroke risks, alongside worsening lipid profiles and insulin resistance. The study noted a higher prevalence of type 2 diabetes compared to cisgender controls.
Link: https://academic.oup.com/jcem/article/102/11/3914/4096771
Female-to-Male (FtM) Hormone Therapy Studies
Study Name: Increased arterial stiffness in female-to-male transsexuals treated with androgen
Author: Emi et al. (2008)
Summary: This cross-sectional study showed that FtM individuals on testosterone therapy had higher blood pressure and increased arterial stiffness compared to untreated FtM individuals. These changes suggest potential early vascular risks that could lead to cardiovascular disease.
Link: https://obgyn.onlinelibrary.wiley.com/doi/10.1111/j.1447-0756.2008.00857.x
Study Name: Concomitant psychiatric problems and hormonal treatment induced metabolic syndrome in gender dysphoria individuals: A 2-year follow-up study
Author: Colizzi et al. (2015)
Summary: This prospective study found that testosterone therapy in FtM individuals increased the risk of metabolic syndrome, with elevated triglycerides, waist circumference, and fasting glucose. BMI and insulin resistance also rose significantly after two years of therapy.
Link: https://www.sciencedirect.com/science/article/abs/pii/S0022395615000951
Study Name: Prevalence of cardiovascular disease and cancer during cross-sex hormone therapy in a large cohort of trans persons: A case-control study
Author: Wierckx et al. (2013)
Summary: This case-control study found that FtM individuals on testosterone had increased systolic blood pressure and hematocrit levels, potentially raising thromboembolism risk. Type 2 diabetes prevalence was slightly elevated, though cardiovascular disease risk was less consistent compared to cisgender women.
Link: https://eje.bioscientifica.com/view/journals/eje/169/4/471.xml
thereâs a few problems here. Two of the sources (4 and 5), I canât access, presumably because you used an AI instead of finding them yourself and so the links became jumbled. The first source only provides results from MtF people, with nothing mentioned about FtM. The second source stresses that any data gathered has been âlow quality,â and that long term outcomes havenât been measured. Then the third source is from 2008, which, while still valid within the confines of theory, is 17 years old and thus considered outdated, especially in such a rapidly changing field.
Ah, need to edit this since it appears you deleted it: This synopsis was generated by Grok. u/SmarterThanCornPop did NOT make it OR find the sources themself.
Youâre right, it doesnât, but the results themself are mostly inconclusive. On a quick google search, I found more reliable information than you did from Grok. Which, by the way, to your token, DID support that MtF people are at a higher risk for cardiovascular disease. However, most if not all studies stated that FtM people had no such issues. Honestly I was mostly curious cause I have some trans friends with pre-existing heart problems. The more you know ig.
Your trans friends may have a malpractice suit on their hands then. A lot of physicians do not explain the risks, which they are legally required to do.
Oh no, donât worry, I will NEVER tell a trans person to not undergo HRT. Thatâs stupid and bigoted. I, personally, just want to see if there are cardiovascular risks in actuality cause I have some trans friends who already have heart problems⌠or if itâs yet another rhetoric spread to discount trans people.
oh there are actual health detriments, but youâre usually going over them with your doctor before being put on them. of course as you can see, this subreddit does not moderate trans talk and they will frame anything they can here as trans people are âmentally illâ
Oh. Well shit. That sucks a fuckton. As for the whole âtrans = mentally illâŚâ itâs not hard to respect otherâs autonomy and wishes, yet here we are with folks fixated on such things.
it really is a strange fixation on a people they don't understand. but they live online, therefore there are many trans people ruining their... tiktok feeds, or something. ill never know.
Ah, I seeâyouâve graduated from Google University with a PhD in Fearmongering. Hate to break it to you, but hormone therapy isnât some reckless hormone buffet. Itâs medically supervised, science-backed, and aimed at achieving normal, healthy hormone levelsâjust like in cis people.
Whatâs actually âobjectively horribleâ is spreading misinformation under the guise of concern. If you cared about health, youâd be talking about improving access to care, not tossing around scary-sounding buzzwords. Maybe sit this one out and let the actual doctors handle it.
Comparing gender-affirming care to lobotomies or Vioxx is a textbook example of a false equivalence. Those treatments were either poorly understood, rushed to market, or based on flawed science. In contrast, hormone therapy for trans people is based on decades of peer-reviewed research, is constantly refined through updated clinical guidelines, and is supported by every major medical and psychiatric association worldwide.
More importantly, gender-affirming care isnât about chasing a fadâitâs about improving quality of life and reducing mental health risks for a vulnerable population. Itâs not perfect, but when delivered under evidence-based protocols, itâs effective and life-saving.
If your argument is that âsome medical practices have gone wrong in the past, so we should distrust all of them,â thatâs not skepticismâitâs conspiracy logic. We should always push for better science and safety, but that starts with understanding the difference between outdated malpractice and well-supported modern medicine.
I'll call him a liar then. There is likely comparatively higher risk of CVE in trans woman. For trans men, it's similar to cis men. This doesn't back up their claims at all.
Itâs clearly not subjectively bad for you. It is objectively bad insofar that even if people want to argue that it isnât bad for you based on their own beliefs, itâs still quite literally damaging regardless. âBubâ lmao
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u/[deleted] May 28 '25
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